Dr. Steven Nissen, Chief Academic Officer, Chief Academic Officer, Sydell and Arnold Miller Family Heart & Vascular Institute discusses the latest techniques in treatment of total coronary total occlusion (CTO) with Dr. Jaikirshan (Jay) Khatri, specialist in CTO care. Dr. Khatri reviews patient selection – who would benefit most from this treatment, including diagnostic testing, clinical and diagnostic criteria; describes interventional techniques such as use of retrograde collaterals and advanced antegrade techniques and how stents are used during these procedures; reviews outcomes and risks of interventional procedures for chronic coronary occlusion; and discusses current research.